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[18] In accordance with the above, MC 4 receptor agonists have garnered interest as potential treatments for obesity and insulin resistance, [19] [20] while MC 4 receptor antagonists have attracted interest as potential treatments for cachexia

doi: 10.3390/ijms23010280 184 MatthayM

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It highlights adipokine-mediated inflammation and macrophage polarization as key drivers of cartilage degradation and suggests integrative therapeutic approaches that address both metabolic and inflammatory factors