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the majority of evidence derives from rodent models

Additionally, microdoses are also helpful for reducing hedonic eating

Recent progress includes an antibody NPY2R agonist with infusion-like exposure resulting in reduction of food intake without emesis (101), Y14, a zinc-based extended-release selective Y2 receptor agonist, that demonstrated preliminary efficacy and tolerability in human subjects (103), and BI 1820237, a long acting NPY2 receptor agonist that showed decreased energy intake and delayed gastric emptying in overweight or obese men (104)

Certain peptides have been studied for their potential to support the body's own regulatory and repair processes