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When this gene has a common variation, that conversion process becomes less efficient

Mizugaki A, et al

Cleveland Clinic explains that this change in body composition can decrease your thirst sensation and decreases your body's ability to conserve water, increasing the risk of dehydration

GSTP1 itself can also function as a target, as has been shown for chemically reactive metabolites derived from acetaminophen (Jenkins et al., 2008) and diclofenac ( Although reactive QI formation has been associated with AQ-induced (cyto)toxicity in vitro (Naisbitt et al., 1998