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Aymond JD

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Declarations Acknowledgement The authors acknowledge DST-FIST for sponsoring the Department of Biotechnology, Central University of Tamil Nadu

Thirdly, advance the development of novel saponin formulations (e.g., nanoparticle-encapsulated, receptor-targeted liposomes, pH-responsive prodrugs) and initiate phase I/II clinical trials combining these optimized formulations with standard chemotherapeutic regimens, focusing on evaluating their in vivo bioavailability, safety profiles (especially hemolytic toxicity and organ tolerance), and clinical efficacy in cancer patients, while establishing unified evaluation criteria for the therapeutic potential of saponin-based combination therapies