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Description

To date, no alterations in the FLNA gene CpG island with the highest probability to have regulatory functions have been found, excluding an epigenetic silencing (81)

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hBMSC-EVs alleviate weightlessness-induced skeletal muscle atrophy by suppressing oxidative stress and inflammation

Mechanisms include reduction of excitotoxicity and oxidative stress, enhanced neurotrophic factor expression supporting neuronal survival, angiogenesis improving cerebral blood flow, and modulation of dopamine and serotonin systems