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This loss directly reduces appetite suppression efficacy and may explain weight loss plateaus in patients using older medication

When GluK2 is bound to the PAM BPAM, the LBD assumes a single stable conformation, characterized by the strengthened D1D1 interfaces of LBD dimers as well as the canonical two-fold symmetrical dimer-of-dimers arrangement of LBDs (Figure 4E)

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2005, Tsounapi et al