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1 Introduction Diabetic nephropathy (DN) is a severe microvascular complication of diabetes mellitus and is the leading cause of end-stage renal disease (ESRD) worldwide, accounting for approximately 40% of ESRD cases ( Histologically, DN is characterized by progressive glomerulosclerosis, tubulointerstitial fibrosis, and abnormal extracellular matrix deposition, resulting in irreversible nephron loss and functional decline (12)