why do glp 1 drugs stop working

why do glp 1 drugs stop working GLP-1 Long-term Success of GLP-1s Hinges

Name: why do glp 1 drugs stop working GLP-1 Long-term Success of GLP-1s Hinges
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Despite a decrease in mitochondrial mass, reactive oxygen species (ROS) formation was increased in cultured RPE cells from patients with AMD [74]

However, not all agents in the class are equivalent

Neurosci Lett (2011) 487:12933.10.1016/j.neulet.2009.06.079 40 SchuelkeMKrudeHFinckhBMayatepekEJanssenASchmelzMet alSepto-optic dysplasia associated with a new mitochondrial cytochrome b mutation

For example, GLP-1RA has been reported to alter free fatty acid and LDL cholesterol levels which are TLR4 ligands 52,53