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1 factors that increase the risk of acetaminophen toxicity Decreased hepatic capacity for glucoronidation Gilberts disease Zidovudine, trimethoprim/sulfamethoxazole Inducers of CYP2E1 (increase metabolism of acetaminophen into toxic NAPQI) Isoniazid Rifampicin, phenobarbital Phenytoin, phenobarbital Hepatic depletion of glutathione Chronic alcohol ingestion Chronic acetaminophen use Chronic liver disease Malnutrition clinical evolution Toxicity is typically divided into stages, but this may not work perfectly in every patient (especially in patients who ingested several doses of acetaminophen over time)