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Indoleamine 2, 3-dioxygenase 1 (IDO1), indoleamine 2, 3-dioxygenase 2 (IDO2), and tryptophan-2, 3-dioxygenase (TDO) catalyze the rate-limiting step of tryptophan catabolism in the kynurenine pathway to consume tryptophan and produce kynurenine

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Consequently, advances in the treatment of T1D could not only provide a cure for this disease but also establish a viable therapeutic paradigm for other forms of diabetes, despite remaining challenges such as achieving precise cellular targeting [1]