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While human clinical trials remain limited, decades of animal research and growing community experience suggest a favorable risk profile when used responsibly

These retrospective studies, although smaller than the large database studies, enable more detailed analysis by virtue of including nuanced data from retinal imaging and longitudinal follow-up after retinopathy development or progression

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The authors reported that B7-H3 downregulation significantly reduces cell migration and matrigel invasion and has no effect on cell proliferation or apoptosis