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Further exploration uncovered that canagliflozin had the capability to increase the expression of -H2AX, a marker of DNA damage, and activated the DNA damage response signaling pathway ATM/CHK2

Regular alcohol use can "rev up" these enzymes, causing your body to produce even more of the toxic NAPQI byproduct than it normally would

Br J Nutr 2000

However, GLP-1 receptor agonists, often prescribed for type 2 diabetes and sometimes for weight management, can affect the entire body - including the oral cavity