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[6] Current evidence suggests that intact NAD+ molecules are unlikely to be absorbed efficiently from the gastrointestinal tract into systemic circulation
This is NOT seen with semaglutide or tirzepatide and is likely related to glucagon receptor activation or rapid metabolic changes
In clinical trials, retatrutide achieved 24.2% weight loss at 48 weeks versus tirzepatide approximately 21% at 72 weeks, suggesting stronger overall appetite and metabolic effects
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