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The combination of 40 M astragaloside IV and 2 M cisplatin (neither concentration exhibiting significant toxicity to HepG2 cells) significantly decreased the cell viability, induce tumor cell apoptosis, slow down the growth of tumor cells both in vitro and in vivo, and improve the chemosensitivity of liver cancer cells to cisplatin by reversing the overexpression of multidrug resistance-associated protein MRP2 in tumor cells induced by cisplatin

In this review article, the authors have provided a detailed overview of these strategies

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Therefore, reliable diagnostic frameworks are necessary to support safer and more informed clinical decisions