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This reduction may influence extracellular matrix remodeling, immune cell recruitment, and paracrine signaling in surrounding tissues
Research has also examined its role in enteric neuron survival, enteric glial cell activity, gut motility modulation, and gut-brain axis signaling in experimental settings
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A retrospective analysis of 105,000+ patients revealed: 40% lower OSA risk with tirzepatide (Zepbound) or semaglutide (Wegovy) vs non-AOM users Lower OSA incidence: 3.12% vs 12.56% Comparable impact between tirzepatide and semaglutide, with tirzepatide showing a slight edge after 6 months This study highlights the potential for AOMs to address obesity and OSA, supporting broader healthcare value through comorbidity reduction
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