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At the very least, that means limiting exposure, when possible, to those ROS-generating compounds that weve mentioned

Results Study design and patient characteristics To identify metabolic signatures associated with shunt responsiveness, we performed a two-stage metabolomics study comprising a discovery screen (semi-targeted) followed by targeted evaluation ( Figure 1 )

Gradual changes escape notice

In addition, we implemented a Random Forest (RF) classifier on the dataset, allowing the model to inherently perform feature selection through its importance ranking, and assessed performance using AUC and precision-recall AUC (PR-AUC)