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CLIC proteins contain Grx-like active site motiv, Cys-Pro-(Phe/Ser)-(Ser/Cys), present also in O-class GSTs [208,220,221]

2 The incidence of immune-related adverse events varies across therapies and clinical trials

In research contexts, investigators typically define model-specific controls, endpoints (for example, scratch-wound assay closure metrics, transwell migration, TEER and barrier-integrity markers, cytokine panels, ECM-related markers), and time points

To further support the impact of CBS on replenishing GSH levels under cystine-restricted conditions, we expressed a codon-optimized CBS (CBS OPT ), which is resistant to the designed sgRNA (Fig