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Although viral vectors are considered relatively safe, there are still some precautions and concerns around them, especially after 1999 when a 20-year-old man died due to an allergic reaction to the vehicle (inactive carrier) during a gene therapy clinical study in Pennsylvania [5]

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References Auchtung TA, Fofanova TY, Stewart CJ, Nash AK, Wong MC, Gesell JR, et al

Reprod Biol Endocrinol 17:19 Codrington AM, Hales BF, Robaire B (2004) Spermiogenic germ cell phasespecific DNA damage following cyclophosphamide exposure