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Potential Benefits: The combination is suggested to potentially enhance fat reduction (especially abdominal fat), improve muscle mass and recovery, and potentially minimize the side effects associated with conventional GH therapy

The interface area of GLP-1(9-36) with GLP-1R increases from 1,891 [GLP-1(9-36) alone] to 3,010 in the presence of LSN3318839, nearly matching that of GLP-1(7-36) (3,316 )

For patients requiring chronic NSAID therapy, proton pump inhibitor (PPI) co-therapy should be considered for gastroprotection, particularly in those with additional risk factors