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Effect of psilocybin and ketamine on brain neurotransmitters, glutamate receptors, DNA and rat behavior

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However, increased DA content has been identified to enhance the rotenone- and MPP + -induced toxicity in various in vitro studies [101, 102]

Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into -ketoglutarate (-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]