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therefore, the overall effect may vary over multi-day treatments ( Benefits are most evident for persistent pain, particularly in postoperative settings, where personalized dosing within multimodal approaches can reduce distress and enhance ventilator synchrony (Figure 3) ( Figure 3 In ventilated preterm infants, routine continuous morphine after a loading dose did not improve pain scores or neurologic outcomes compared with placebo, although a slight reduction in any grade of intraventricular hemorrhage (IVH) was observed (Table 2) (60)