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Studies in DSS and TNBS mouse models as well as in vitro experiments have shown that amino acids not only serve as substrates for energy production and biosynthesis, but also influence the M1/M2 macrophage balance through metabolic pathways, thereby regulating intestinal inflammation
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For the pathways using precursors that require a phosphoribosyl moiety, such as NAM and nicotinic acid (NA), PRPP is required 22
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