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Despite employing conservative assumptions in this work, the primary source of uncertainty stems from the absence of any formal guidance on the parameterization of these models and validation data, unlike the well-established validation of physiologically based kinetic models against human clinical data (Li et al., 2021

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Unfortunately, the common precancerous lesion of PC, pancreatic intraepithelial neoplasia, cannot be recognized by conventional detection methods such as CT or other cross-sectional imaging diagnostic techniques [268]

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