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Individuals with severe kidney disease: GLP-1 medications can sometimes affect kidney function

It does this by increasing insulin production in response to food intake and by slowing down the emptying of the stomach

Women of childbearing age should be aware that Wegovy is contraindicated in pregnancy and should be discontinued at least two months before a planned pregnancy, while levothyroxine requirements typically increase during pregnancy

This metabolite reduces ammonia elimination through inhibition of carbamoyl-phosphate synthase I, the first enzyme in the urea cycle, resulting in increased ammonia levels [107]