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Melanotan-1 (afamelanotide) is a selective MC1R agonist producing melanogenesis with minimal off-target effects, while Melanotan-2 binds MC1R, MC3R, and MC4R causing appetite suppression, spontaneous erections, and nausea at higher rates

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Combined administration of tesamorelin with ipamorelin is therefore outside tesamorelin's narrow FDA approval

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