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In terms of antioxidant capacity, YTHDF1 knockdown significantly reduced MDA levels and elevated SOD and GSH-PX activities, however, SLC7A5 overexpression reversed these beneficial changes (Fig

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For example, lung cancer cell-lines show different sensitivities to doxorubicin in the form of GSH depletion, with A549 and GLC 4 210(S) cells experiencing approximately 50% and 64% GSH depletion after a 12 hour exposure to 70 nM and 5 nM (per million cells) respectively 37