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The next, phase 1b clinical trial in adults with T2DM compared once weekly retatrutide (0.5, 1.5, 3, 3 mg starting dose increased to 6, 3 mg starting dose increased to 12 mg) versus placebo versus dulaglutide 1.5 mg over 12 weeks [63]

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Safety Considerations and Possible Side Effects B12 is generally safe, but there are some side effects and safety issues to watch out for