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Mounjaro (tirzepatide) is manufactured by Eli Lilly and received FDA approval in 2022 for type 2 diabetes in adults and children aged 10 and older

Finally, animal-to-human translational limitations are significant: germ-free mouse models and CUMS paradigms involve physiological conditions that do not faithfully recapitulate human psychiatric or functional gastrointestinal disorders, and microbiota transplant experiments in rodents cannot be directly extrapolated to clinical practice

When mitochondrial glutathione becomes depleted, oxidative damage accelerates at the primary site of ROS generation

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