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Cellular entry of Na + and Ca 2+ through their respective channels is essential for the parasites optimal growth and reproduction [404]

ACI is primarily indicated for younger, active patients with isolated, symptomatic full-thickness defects larger than 22.5 cm 2 , and is generally not recommended in advanced OA with diffuse degeneration (Minas et al., 2010

It contains a combination of B vitamins, including vitamin B12 (cyanocobalamin), thiamine (B1), riboflavin (B2), pyridoxine (B6), nicotinamide, and D-panthenol, which support nerve health, the formation of red blood cells, and energy metabolism

It is noteworthy that the CNS-residing NSPCs show many biochemical and morphological differences throughout life, but the origin of adult NSPCs -type B cells- has been traced from early neurodevelopmental stages (Merkle et al., 2004)