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These substrates include aconitase (Aco) [40], uracil-DNA glycosylase isoform 1 [41], frataxin [42], cystathionine -synthase [43], DAP3-binding cell death enhancer 1 [44], mitochondrial calpain 10 [45], 5-aminolevulinic acid synthase [46], and more

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The weight continued to increase due to lack of exercise and going to physical therapy multiple times a week due to previous injury

Altogether, initial reports of NAD + precursors and exercise in clinical trials, while encouraging in certain instances, are still too inconclusive to directly link an increase in NAD + levels and mitochondrial metabolism to established health benefits in humans