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Bioavailability is the degree and rate at which a substance is absorbed into the bloodstream and becomes available at the intended site of action

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doi: 10.1016/j.bbadis.2017.03.003 16 GreenfieldJRMillerJWKeoghJMHenningESatterwhiteJHCameronGSet al

However, the EMPA-REG OUTCOME trial with empagliflozin, the DECLARE-TIMI 58 trial with dapagliflozin, and the VERTIS CV trial with ertuglifozin did not report an increase in amputations in the patients treated with an SGLT2 inhibitor (143,156,160,230)