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Those treated with semaglutide 2.4 mg had greater beneficial changes in HbA 1c , fasting glucose, waist circumference and systolic blood pressure than the placebo group at week 52, and off treatment these parameters increased but did not reach baseline levels at week 80

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its activation would lead to intracellular Na + retention, thus enhancing Na + /Ca 2+ exchange and H 2 O reabsorption (95, 96)

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