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Animal reproduction studies, required for FDA approval, have shown some findings that warrant consideration

Diet-induced obese (DIO) male rats were treated with (1) vehicle with ad libitum feeding (V), (2) CagriSema with ad libitum feeding (CS), (3) vehicle with pair-feeding matched to the caloric intake of the CS rats (PF) or (4) vehicle with caloric restriction to match the weight of the CS rats (weight matched (WM)) (Fig

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