To view a copy of this license, visit About this article Cite this article Wang, Y., Guo, S., Zhuang, Y
Overall, the biosynthesis of 20 essential amino acid families are grouped by metabolic precursors 62 (Table 3)
* Skin lacking firmness or elasticity
AIFM1 mutations have been associated with wide spectrum of clinical phenotypes with X-linked recessive inheritance including a severe, early-onset mitochondrial encephalomyopathy with combined oxidative phosphorylation deficiency [155] , prenatal ventriculomegaly [156] , the Cowchock syndrome, an X-linked Charcot-Marie-Tooth disease (CMTX4) with axonal sensorimotor neuropathy, deafness and cognitive impairment [157] , auditory neuropathy spectrum disorder [158] , spondyloepimetaphyseal dysplasia with mental retardation [159] , and, more recently, cerebellar ataxia partially responsive to riboflavin [160]