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These advances also align with the emerging paradigm of precision medicine in obesity, in which genetic predictors of response and adverse effects to GLP-1-based therapies may enable more individualized treatment strategies [24]

Key Endpoints in Translational Diet-induced Obese Rodent Models Diet-induced obese (DIO) mice and rats represent the standard translational obesity models in preclinical drug discovery, where excessive caloric intake and the drive for weight regain plays a major role in the etiology, pathology and progression of the disease