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The redesign simplifies the platforms application process, allowing DOD components to advance innovative ideas more efficiently

One major pathway is related to their redox activity: copper ions generate reactive oxygen species (ROS) via Fenton or Fenton-like reactions 2,4

Oxidative stress also contributes to necrosis by damaging cell membranes through lipid peroxidation and exacerbating calcium dysregulation, leading to cell swelling and lysis (Munoz et al., 2017

"Contraction of the rat isolated aorta caused by Clostridium perfringens alpha toxin (phospholipase C): evidence for the involvement of arachidonic acid metabolism"