doi: 10.1007/s10753-017-0600-y 111 LiXYuanKZhuQLuQJiangHZhuMet al
Water/Aqua/Eau, Tetrahexyldecyl Ascorbate (vitamin C/antioxidant), Dimethicone (silicone/emollient), Glycerin (humectant), C912 Alkane (solvent), Ascorbyl Glucoside (vitamin C/antioxidant), Silica (texture enhancer), Pyrus Malus (Apple) Fruit Extract (plant extracts/antioxidant), Hydrogenated Lecithin (emollient), Polyglyceryl6 Polyricinoleate (emulsifier/suspending/dispersing agent), Acrylates/C1030 Alkyl Acrylate Crosspolymer (texture enhancer), Xanthan Gum (texture enhancer), Glutathione (antioxidant), Ergothioneine (antioxidant), Oryza Sativa (Rice) Bran Extract (plant extracts/antioxidant), Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer (suspending/dispersing agent), Cetyl Alcohol (emollient), Caprylyl Glycol (humectant), Lysine Carboxymethyl Cysteinate (antioxidant), CocoCaprylate/Caprate (emollient), Tocopherol (vitamin E/antioxidant), Sodium Citrate (pH adjuster), Sodium Phytate (chelating agent), Hexylene Glycol (humectant), Ethylhexylglycerin (humectant), Helianthus Annuus (Sunflower) Extract (plant extracts/antioxidant), Urea (humectant), Mannitol (humectant), Caprylic/Capric Triglyceride (emollient), Sodium PCA (humectant), Rosmarinus Officinalis (Rosemary) Leaf Extract (plant extracts/antioxidant), Polysorbate 60 (emulsifier), Sorbitan Isostearate (emulsifier), Trehalose (humectant), Ascorbic Acid (vitamin C/antioxidant), Glucose (humectant), Vanilla Planifolia Fruit Extract (plant extracts/antioxidant), Polyquaternium51 (filmforming agent), Triacetin (solvent), Sodium Hyaluronate (humectant), Phenoxyethanol (preservative)
IGF-1 displays more binding sites for SHP2 (a phosphatase related to growth) and seems more prone to recruit Cbl [121] (an E3 ligase that targets the receptor for ubiquitination and destruction) and thus may explain a different regulatory mechanism not mediated by serine phosphorylation, and thus not so sensitive to metabolic derangements
CONFLICT OF INTEREST STATEMENT The authors have no conflict of interest to declare
