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This phenomenon is clearly observed in the STEP 2 trial of semaglutide (2.4 mg weekly), where a cumulative 33.7% of patients with obesity and T2D reported nausea throughout the duration of the trial ( It has been hypothesized that the deleterious, nauseating effects of GLP-1R agonists and the beneficial, food-intake reducing effects are inextricably linked

Dose: The starting dose of Ozempic is 0.25 mg once a week and titrates up to 2 mg once a week

Unusual bruising, bleeding, or severe allergic symptoms should not wait for routine lab follow-up