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Analysis on datasets from Cancer Genome Atlas (TCGA) of the expression of LDLR and HMGCR in ovarian cancer patients, as well as a retrospective study on 65 patients found that patients with a high expression of LDLR and low expression of HMGCR in their tumors, had a poorer disease-free survival, as well as a poorer overall survival, compared to patients with a low LDLR expression [115]

The findings underscore glutathione's protective function in brain health and indicate that stress-related pathways affecting antioxidant systems may represent new avenues for medication development in treating depression

doi: 10.1016/j.therap.2020.07.008 44 MicallefJ.SoeiroT.Jonville-BraA