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Production of IGF-1 and the most abundant binding protein in plasma, IGFBP-3, occurs via growth hormone-mediated signaling, and insulin influences IGF-1 bioavailability by controlling the transcription of IGFBP-1

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As a border collie mix, Yuki may also have been a carrier for intestinal cobalamin (B12) malabsorption, the genetic mutation originally found in border collies

But it does mean you're accepting risks that don't exist with topical application, for benefits that may not be meaningfully greater