Under the CMMI demo, as Medicare reduces the prices it pays to Eli Lilly and Novo Nordisk for GLP-1s to treat diabetes, cardiovascular disease, and possible future indications, it can use the savings to pay for the expansion of coverage for GLP-1 drugs solely for weight loss
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"Orforglipron (LY3502970), a novel, oral non-peptide glucagon-like peptide-1 receptor agonist: A Phase 1b, multicentre, blinded, placebo-controlled, randomized, multiple-ascending-dose study in people with type 2 diabetes"
In the dimer form, the GH portion of one molecule bound to the receptor portion of another molecule in a head-to-tail reciprocal dimer