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Inactivating mutations in the inwardly rectifying potassium channel 2.6 encoded by the KCNJ18 gene (in about 30%) have, among other candidates, been associated with susceptibility for developing thyrotoxic periodic paralysis (334, 335)
The alkylating chemotherapeutic temozolomide induces metabolic stress in IDH1-mutant cancers and potentiates NAD(+) depletion-mediated cytotoxicity
[PMC free article: PMC4159082] [PubMed: 22508840] 686
This could lead to better hormone balance and metabolism in PCOS patients ( The relationship link between high homocysteine levels and PCOS, as well as the positive outcomes of B-complex vitamin supplementation on homocysteine metabolism, indicate that these vitamins might offer useful therapeutic value in managing PCOS
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