BPC-157 is an experimental peptide, and it has not been approved by the FDA to diagnose, treat, cure, or prevent any disease
It was identified through a medicinal chemistry programme at the University of Texas Health Science Center as the lead NNMT inhibitor candidate among a series of 1-methylquinolinium analogues bearing primary amine substitutions, selected for its combination of high passive membrane permeability (confirmed in PAMPA assays), high active transport membrane permeability (confirmed in bidirectional Caco-2 cell assays), potent NNMT inhibitory activity, and high selectivity including confirmed absence of inhibitory effects on related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway
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Patients were randomized into three different treatment arms for 48 hours: Bolus group (bl) = furosemide 80 mg IV boluses, twice daily Continuous group (cIv) = IV furosemide 160 mg/day, given as a continuous infusion over 16 hours Hyperdiuresis group (HSS) = 160 mg IV furosemide plus 150 ml of 2% NaCl, twice daily infused over 30 minutes Patients in the hyperdiuresis group had shorter hospital length of stay (table below)
