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The BENDIP study demonstrated that neuropathic symptoms, measured using the NIS as the primary endpoint, improved after 6 weeks of treatment with benfotiamine at a dose of 300 mg twice daily (no improvement was observed with 300 mg once daily) [71]

Moreover, increased SR-E1 in SLE is associated with elevated IL-8 and reduced IFN- levels, while other cytokines such as IL-6, IL-10, and TNF- remain unchanged (105)

The reason behind this is that they can enhance metabolic function, encourage fat export from the liver, and provide nutritional support

For severe cases, the first dose is usually 1,000 mcg given intramuscularly every day or every other day for a week or two