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After retatrutide, significant drops in these enzymes were seen, more at higher doses

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Practical Differences: What This Means for Treatment Understanding GLP-1 versus GIP matters when choosing between medications or understanding why one might work better for you than another

When to pause or reverse the taper Red flags that should pause your taper include weight gain exceeding 3% of your lowest weight, significant increase in hunger that interferes with daily functioning, worsening metabolic markers such as rising blood sugar, blood pressure, or lipid levels, return of binge eating patterns or loss-of-control eating episodes, and significant emotional distress related to appetite changes