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Dorr et al

Signs of Vitamin B12 Deficiency Some common signs that you may be deficient in Vitamin B12 include fatigue or tiredness, weakness, difficulty concentrating or thinking clearly, pale skin, dizziness or light-headedness, loss of appetite, weight loss, constipation or diarrhea, numbness or tingling in the hands and feet, sore tongue, headaches and vision problems

More specifically, researchers have observed that senescent cells resisted apoptosis due to elevated FOXO4 levels, which seem to regulate this process by interacting with p53