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For pediatric patients, a study investigating liraglutide treatment in a male with a homozygous LOF MC4R variant (c.750_751del p.Ile251fsTer34) - accompanied by severe insulin resistance, non-alcoholic fatty liver disease, and obstructive sleep apnea - has also indicated therapeutic benefits [69]
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8 Regulatory, commercial, and practical considerations in advancing underexplored peptide systems Scientific plausibility alone is insufficient to advance underexplored peptidereceptor systems into approved therapeutics
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