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The information provided here is based on publicly available research and data as of April 2026 and may not reflect the most current medical guidelines

If heart failure develops, it should be managed according to current standards of care, and discontinuation or dose reduction of the PPAR-gamma agonist must be considered

This durability reflects genuine metabolic adaptation rather than temporary calorie restriction

Treatment Options at Calibrate Calibrate clinicians prescribe only FDA-approved GLP-1 medications, the same ones used in clinical trials and covered by most commercial insurance plans: Weekly injectables: Wegovy, Ozempic, Mounjaro, Trulicity, Zepbound Note: Ozempic, Moujaro, and Trulicity are FDA approved for type 2 diabetes and must be prescribed off-label for weight loss