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Studies conducted on Nrf2 knockout mice have shown certain changes in the lens, including disruptions in cortical cell architecture, abnormal presence of nuclei in deeper lens regions, and ectopic nuclei in the posterior region

The NOR test primarily relies on the perirhinal cortex, which is influenced by the hippocampus and synaptic plasticity, and is based on the natural preference of rodents to investigate novel objects over familiar ones (Antunes and Biala, 2011)