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Compared to these studies, contrasting results have been collected from a big multicenter phase III RCT (the PIVENS trial) which involved 247 non-diabetic patients with biopsy-proven NASH and compared vitamin E versus pioglitazone versus placebo after a 96-week treatment period

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doi:10.1016/j.jpba.2010.10.013 Kumar Talluri MVN, Dharavath S, Kalariya PD et al (2015) Structural characterization of alkaline and oxidative stressed degradation products of lurasidone using LC/ESI/QTOF/MS/MS